Alpha Gro to a biopsy is a early marker of TTR amyloid it uptake occurs in patients actually intriguingly even before at times the wall Alpha Gro seconds or they develop significant diastolic dysfunction and so in the Cascade of amyloid in which we're trying to identify people earlier we could move from where we used Alpha Gro to be with low voltage or symptoms or echocardiographic findings down the amyloid cascade to identify .
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